SETting Up for Epigenetic Regulation of Advanced Prostate Cancer.

TitleSETting Up for Epigenetic Regulation of Advanced Prostate Cancer.
Publication TypeJournal Article
Year of Publication2020
AuthorsThienger P, Rubin MA
JournalCancer Cell
Volume38
Issue3
Pagination309-311
Date Published2020 09 14
ISSN1878-3686
KeywordsAMP-Activated Protein Kinases, Cell Line, Tumor, Enhancer of Zeste Homolog 2 Protein, Epigenesis, Genetic, Gene Expression Regulation, Neoplastic, Humans, Male, Prostatic Neoplasms, Receptors, Androgen
Abstract

An outgrowth of therapy-resistant prostate cancers (PCa) with enhanced metastatic potential may be triggered by inhibitors of androgen receptor (AR) signaling, often via epigenetic rewiring. In this issue of Cancer Cell, Yuan et al. demonstrate how SETD2 integrates EZH2 and AMPK signaling pathways to keep PCa metastasis in check.

DOI10.1016/j.ccell.2020.08.009
Alternate JournalCancer Cell
PubMed ID32931739
PubMed Central IDPMC8404154
Grant ListP50 CA211024 / CA / NCI NIH HHS / United States