The Weill Cornell Medicine (WCM) Specialized Programs of Research Excellence (SPORE) in Prostate Cancer is a key center for paradigm-shifting translational research. We aim to establish new approaches to treating PCa, which will result in improved patient outcomes and quality of life. The WCM SPORE Program endeavors to develop translational research projects with precision medicine approaches to patient care across the Prostate Cancer (PCa) Spectrum. The four SPORE projects focus on the detection and treatment of aggressive and treatment-resistant Prostate Cancer. The Developmental Research Program (DPR) will aim to attract investigators across a rich, multi-disciplinary landscape to focus on PCa translational research. The Career Enhancement Program (CEP) is committed to the development of junior faculty and future leaders in the field.