Submitted by sag4013 on October 26, 2021 - 5:09pm
Title | Prostate Stem Cells and Cancer Stem Cells. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Li JJ, Shen MM |
Journal | Cold Spring Harb Perspect Med |
Volume | 9 |
Issue | 6 |
Date Published | 2019 06 03 |
ISSN | 2157-1422 |
Keywords | Animals, Epithelial Cells, Humans, Male, Mice, Models, Biological, Neoplastic Stem Cells, Prostate, Prostatic Neoplasms, Receptors, Androgen, Stem Cells |
Abstract | Stem/progenitor cells play central roles in processes of organogenesis and tissue maintenance, whereas cancer stem cells (CSCs) are thought to drive tumor malignancy. Here, we review recent progress in the identification and analysis of normal prostate stem/progenitor cells as well as putative CSCs in both genetically engineered mouse models as well as in human tissue. We also discuss studies that have investigated the cell type of origin for prostate cancer. In addition, we provide a critical assessment of methodologies used in stem cell analyses and outline directions for future research. |
DOI | 10.1101/cshperspect.a030395 |
Alternate Journal | Cold Spring Harb Perspect Med |
PubMed ID | 30291148 |
PubMed Central ID | PMC6546034 |
Grant List | P50 CA211024 / CA / NCI NIH HHS / United States R01 CA196662 / CA / NCI NIH HHS / United States |