Submitted by sag4013 on October 26, 2021 - 5:13pm
| Title | Prostate Power Play: Does Pik3ca Accelerate Pten-Deficient Cancer Progression? |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Triscott J, Rubin MA |
| Journal | Cancer Discov |
| Volume | 8 |
| Issue | 6 |
| Pagination | 682-685 |
| Date Published | 2018 06 |
| ISSN | 2159-8290 |
| Keywords | Animals, Class I Phosphatidylinositol 3-Kinases, Humans, Male, Mice, Orchiectomy, Phosphatidylinositol 3-Kinases, Prostatic Neoplasms, PTEN Phosphohydrolase |
| Abstract | PI3K pathway alterations are frequently recurrent in metastatic prostate cancer and are associated with the development of currently incurable castration-resistant disease. Candidate inhibitors that target single PI3K pathway members lack efficacy as demonstrated in multiple clinical trials. In this issue, Pearson and colleagues examine the functional importance of co-occurring PIK3CA and PTEN aberrations using a novel mouse model and demonstrate a synergistic acceleration of tumorigenesis that may be responsible for de novo metastatic prostate cancer. Cancer Discov; 8(6); 682-5. ©2018 AACRSee related article by Pearson et al., p. 764. |
| DOI | 10.1158/2159-8290.CD-18-0369 |
| Alternate Journal | Cancer Discov |
| PubMed ID | 29858226 |
| Grant List | P50 CA211024 / CA / NCI NIH HHS / United States |