Submitted by sag4013 on October 26, 2021 - 5:08pm
Title | Retinoblastoma Loss in Cancer: Casting a Wider Net. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Choudhury AD, Beltran H |
Journal | Clin Cancer Res |
Volume | 25 |
Issue | 14 |
Pagination | 4199-4201 |
Date Published | 2019 07 15 |
ISSN | 1557-3265 |
Keywords | Genes, Retinoblastoma, Humans, Retinoblastoma, Retinoblastoma Protein, Transcriptome |
Abstract | Capturing both genomic and nongenomic mechanisms of retinoblastoma gene dysfunction has potential to improve risk stratification and patient selection for biomarker-driven therapy. A 186-gene expression signature is capable of identifying Rb loss across cancer types, providing a new framework for assessing Rb dysfunction based on transcriptome data.See related article by Chen et al., p. 4290. |
DOI | 10.1158/1078-0432.CCR-19-1292 |
Alternate Journal | Clin Cancer Res |
PubMed ID | 31101725 |
PubMed Central ID | PMC6635068 |
Grant List | P50 CA090381 / CA / NCI NIH HHS / United States P50 CA211024 / CA / NCI NIH HHS / United States |