Submitted by sag4013 on October 26, 2021 - 5:02pm
| Title | SETting Up for Epigenetic Regulation of Advanced Prostate Cancer. |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Thienger P, Rubin MA |
| Journal | Cancer Cell |
| Volume | 38 |
| Issue | 3 |
| Pagination | 309-311 |
| Date Published | 2020 09 14 |
| ISSN | 1878-3686 |
| Keywords | AMP-Activated Protein Kinases, Cell Line, Tumor, Enhancer of Zeste Homolog 2 Protein, Epigenesis, Genetic, Gene Expression Regulation, Neoplastic, Humans, Male, Prostatic Neoplasms, Receptors, Androgen |
| Abstract | An outgrowth of therapy-resistant prostate cancers (PCa) with enhanced metastatic potential may be triggered by inhibitors of androgen receptor (AR) signaling, often via epigenetic rewiring. In this issue of Cancer Cell, Yuan et al. demonstrate how SETD2 integrates EZH2 and AMPK signaling pathways to keep PCa metastasis in check. |
| DOI | 10.1016/j.ccell.2020.08.009 |
| Alternate Journal | Cancer Cell |
| PubMed ID | 32931739 |
| PubMed Central ID | PMC8404154 |
| Grant List | P50 CA211024 / CA / NCI NIH HHS / United States |